I think it will be a very significant decision. It probably will have broader scope than either In re Comiskey or In re Nuijten.

I doubt that the judges will kick software patents out, even if Judge Plager mentioned his regrets:

Plager said he regretted the unintended consequences of the decisions in State Street Bank and AT&T. Those rulings led to a flood of applications for software and business method patents, he noted. If we “rethink the breadth of patentable subject matter,” he said, we should ask whether these categories should be excluded from patent protection.

United States law on patentability does not need to be stretched:

Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent. (35 U.S.C. § 101)

Some patent lawyers will of course argue that software is a process (data processing), but I doubt it will be enough to convince all the judges.